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PPI Therapy related information | PPI Therapy SYMPTOMS: Learn about the symptoms of acid reflux disease DRUGS: Common medications used to treat heartburn TREATMENT: Lifestyle changes, medication, and surgeryoptions Last Updated: 10/29/2004 Related Encyclopedia • Abdominoplasty • Acidophilus • Adhesions • Amebiasis More... Related Healthscout Videos Nutrition and Cancer Nutrition and Osteoporosis Importance of Good Nutrition Critical Nutrition More... Related Animations • GERD More... Related Drug Information • Aciphex • Nexium • Prevacid • Prilosec More... Related News Articles • New Findings about Drug-Covered Stents • Autoimmunity Cells Found in Healthy Adults • Dangerous Prenatal Condition Linked to Exercise • New Insight into How Cells Get Nutrients More... PPI Therapy The inner surface of the stomach is formed into numerous gastric pits from which acid is secreted. The cells lining the gastric pits are: Mucous neck cells which secrete mucous, The G cells which secrete gastin The parietal cells which secrete hydrochloric acid The proton pump present in parietal cells is responsible for acid secretion The proton pump is located in the luminal side of the parietal cell Parts: Proton pump Proton Potassium ATP The proton pump actively transports proton into the stomach lumen and potassium back to the parietal cell with hydrolysis of ATP. Proton pump inhibitors are drugs which reduce acid secretion of the stomach. The drug passes unchanged through the stomach and is absorbed in the small intestine. The drug binds irreversibly to the proton pump and prevents the active transport of protons. This dramatically decreases the acid secretion of the stomach.